Anti-mycobacterium phlei activity of the bark of Ziziphus talanai(Blanco) Merrill
2009
Añas, A.R.J. | Villaseñor, I.M., Philippines Univ. Diliman, Diliman, Quezon City 1101 (Philippines). Natural Products Rsearch Lab. | Matsuura, H. | Okino, T., Hokkaido Univ., Sapporo 060-0810 (Japan). Faculty of Environmental Earth Science
The bark of Ziziphus talanai(Blanco) Merrill, a tree endemic to the Philippines, is traditionally used in Antique [Philippines] to cure Kidney problems such as urinary tract infections(UTI), and skin diseases such as scabies and ringworm. Its antimicrobial activity was screened against several microorganism to have a more comprehensive anti-infective profile of the plant. The MeOH extract of Z.talanai bark exhibited antimicrobial activity against Gram-positive Mycrobacterium phlei, Staphylococcus aureaus and Bacillus subtilis at 20,000 micro g and 2,000 micro g but was inactive against Gram-negative Escherichia coli, Pseudomonas aeruginosa, Candida albicans, and Saccharomyces cerevisiae. It has minimal antifungal activity against T. mentagrophytes. The MeOH extract of Z. talanai is therefore inactive against uncomplicated UTI, which is mostly caused by E. coli. Further bioassay-guided isolation and subsequent spectral analysis yielded ceanothic acid, whose activity is specific to M.phlei at 100 micro g. M.phlei causes chronic ambulatory peritoneal dialysis-associated peritoritis.
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