On the efficacy of eugenol in the treatment of sheep mange
2011
Aleksic, N., Faculty of Veterinary Medicine, Belgrade (Serbia) | Jezdimirovic, M., Faculty of Veterinary Medicine, Belgrade (Serbia) | Jezdimirovic, N., Scientific Veterinary Institute of Serbia, Belgrade (Serbia)
Given that sheep mange is an infection of utmost importance, it is plausible that research has continuously been performed with the aim of invention of new means of combat against its causative agents. The currant research was carried out on the acaricide efficacy, tolerance and safety of 10 and 20% eugenol in the treatment of sarcoptic mange in sheep. The results were compared with the ones of benzyl benzoate (25%); both substances were rubbed into skin of sheep three times in seven-day intervals. Skin scrapings were sampled seven days after each treatment, as well as twenty-eight days following the third one. The changes on the skin were quantified and the mean recovery response (MRR) was calculated. The clinical efficacy was assessed according to the MRR and the number of mites in the skin samples. Following the first treatment 10% eugenol was insignificantly less efficacious in comparison with its higher concentration. Having been applied twice 20% eugenol was significantly more efficacious when compared to the lower concentration, which remained the same seven and twenty-eight days after the third application. The efficacy of 10% eugenol in the therapy of mange was significantly higher in comparison with benzyl benzoate following one, two or three administrations. The efficacy of benzyl benzoate four weeks after the third treatment was still significantly lower in comparison with 10% eugenol. The efficacy of 20% eugenol was significantly higher in comparison with its lower concentration, as well as that of benzyl benzoate following the second, and seven and twenty-eight days after the third one. No signs of local or systemic intolerance were noticed in sheep treated with either 10 or 20% eugenol or 25% benzyl benzoate.
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