Study on adrenal gland morphology in mice treated with monosodium glutamate
2007
Bojanović, M., Faculty of Medicine, Niš (Serbia). Clinical Center | Spalević, M., Faculty of Medicine, Niš (Serbia). Clinical Center | Simonović, M., Faculty of Medicine, Niš (Serbia). Clinical Center | Cekić, S., Faculty of Medicine, Niš (Serbia). Institute of Physiology | Aggelopoulou, T., Institute of Nuclear Medicine, Thessaloniki (Greece) | Mohhammad, A., Medical Center of Xanthy, Xanthy (Greece) | Katić, V., Faculty of Medicine, Niš (Serbia). Clinical Center
Monosodium glutamate is neurotoxin, potentially toxic to everyone - even to those people who do not respond with adverse reactions such as migraine headache, asthma, nausea and vomiting, fatigue, disorientation, and depression. However, it is used worldwide to improve the food preference. Hypothalamic lesions induced by neonatal treatment with MSG are primary in the preoptic and arcuate nuclei and in the median eminence, resulting in Cushing's obesity, stunted growth, lethargy and sterility. Having in the mind the contradictory data on the role of the adrenal glands in this type of obesity, the objective of the present experiment was to study MSG-effect on the adrenal gland morphology. Seven newborn C57BL/6J mice, 9 days after the birth, were injected daily with MSG (4.4mg/g body WT) sc. Controls received no treatment. Mice were killed at 4 months of age, and the adrenal glands were removed. For histologicalstudies, specimens were fixed in 10% formalin, routinely processed and embedded in paraffin. Each section (5nm in thickness) was stained with HE, Van Gieson and PAS techniques, and observed microscopically. Besides Cushing's obesity, the most important morphological finding was hypertrophy of both adrenal glands, compared with controls. Microscopically, the cortex was widened and composed predominantly of fasciculate cells with large cells and abundant intracytoplasmic lipid droplets showing microvesicular pattern. Thus, the authors confirm the suggestion that mice neonatal treatment with MSG causes a complex disruption of the hypothalamic-pituitary-adrenal axis.
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