Biochemical studies on metalaxyl in experimental animals
2011
Ali, T.A.A.
The present study carried out to through light on toxicological effects of metalaxyl technical pesticides on some physiological and biochemical prameters (Rattus rattus ) in albino rat was treated with metalaxyl orally by gavage at concentrations (0, 50, 100, 150 and 200 mg/kg of pesticide). For a period of 28 days.. The blood samples were collected weekly from eye vein with cappillary tube and plasma was gained to investigate the hematological markers and biochemical parameters in plasma also segments of the livers and kidneys of treated animals treatment and control used for histopathological examination. The main results of these studies indicated that: RBCs count, Hb conc, MCH, MCHC value, albumin value, creatinine level, ãGT activity Total cholesterol, Triglycerides level, Glucose, phosphorous levels were significant decrease through the experimental periods, While WBCs count, MCV, PCV value, HDL levels, ALP, ALT, AST enzymes activity, Urea, calcium concentration, Phospholipids level in generally were significant increase, Also, the results indicated that, Total Protein and globuline levels were slightly increase through the experimental periods in metalaxyl treated animals Pathological changes are observed when the pesticide dose increases in liver tissue and kidney tissue.
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