Evaluation of Solvent Extraction on the Anti-Inflammatory Efficacy of Glycyrrhiza uralensis
2010
Yoon, T.S., Center of Herbal Resources Research, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea | Cheon, M.S., Center of Herbal Resources Research, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea | Kim, S.J., Center of Herbal Resources Research, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea | Lee, A.Y., Center of Herbal Resources Research, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea | Moon, B.C., Center of Herbal Resources Research, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea | Chun, J.M., Center of Herbal Resources Research, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea | Choo, B.K., Chonbuk National University, Jeonju, Republic of Korea | Kim, H.K., Center of Herbal Resources Research, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea
Glycyrrhiza uralensis (Leguminosae) is a well-known herbal medicine that has long been valued as a demulcent to relieve inflammatory disorders. To compare the influence of different solvents on the anti-inflammatory efficacy of G. uralensis, we measured the inhibition of pro-inflammatory mediators such as NO, TNF-α, and PGE₂ in lipopolysaccharide (LPS)-stimulated mouse macrophage RAW 264.7 cells by extracts produced using different solvents (water, methanol, ethanol, or n-hexane). The results showed that methanol was the most effective solvent for the inhibition of both NO and PGE₂ production in RAW 264.7 cells. However, there was no difference among the extracts for inhibition of TNF-α. Further study must be performed for the analysis of correlation between the anti-inflammatory activity of extracts produced using different solvents and the content of major bioactive compounds in G. uralensis, such as glycyrrhizin and liquiritin. The present study suggests that methanol may be a more appropriate solvent of G. uralensis than other solvents (water, ethanol, and n-hexane) to yield the greatest anti-inflammatory activity for food additives and medicine.
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