Cytotoxic Compounds from the Fruits of Vitex rotundifolia against Human Cancer Cell Lines
2012
Kim, H.J., Korea Institute of Oriental Medicine, Daejeon, Republic of Korea | Yi, J.M., Korea Institute of Oriental Medicine, Daejeon, Republic of Korea | Kim, N.S., Korea Institute of Oriental Medicine, Daejeon, Republic of Korea | Lee, Y.J., Korea Institute of Oriental Medicine, Daejeon, Republic of Korea | Kim, J.H., Korea Institute of Oriental Medicine, Daejeon, Republic of Korea | Oh, D.S., Korea Institute of Oriental Medicine, Daejeon, Republic of Korea | Oh, S.M., Korea Institute of Oriental Medicine, Daejeon, Republic of Korea | Bang, O.S., Korea Institute of Oriental Medicine, Daejeon, Republic of Korea | Lee, J., Korea Institute of Oriental Medicine, Daejeon, Republic of Korea
Activity-guided fractionation of an ethanol extract from the fruits of Vitex rotundifolia led to the isolation of three flavonoids (1-3), one lignan (4), and three phenolic compounds (5-7). The structures of compounds 1-7 were identified by NMR data. The efficacy of all compounds was evaluated by their cytotoxic activities against nine human cancer cell lines using an in vitro assay.
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