Effect of type of TAG fatty acids on lutein and zeaxanthin bioavailability

GlEIZE , Beatrice
        INRA
        , Marseille .
         UMR 1260 Nutrition, Obésité et Risque Thrombotique; Tourniaire , Franck
        INRA
        , Marseille .
         UMR 1260 Nutrition, Obésité et Risque Thrombotique; Depezay , Laurence
        .; Bott , Romain
        INRA
        , Avignon .
         UMR 0408 Sécurité et Qualité des Produits d'Origine Végétale; Nowicki , Marion
        INRA
        , Marseille .
         UMR 1260 Nutrition, Obésité et Risque Thrombotique; Albino , Lionel
        .; Lairon , Denis
        INRA
        , Marseille .
         UMR 1260 Nutrition, Obésité et Risque Thrombotique; Kesse-Guyot , Emmanuelle
        INRA
        , Bobigny  Cedex .
         UMR 1125 Epidémiologie Nutritionnelle; Galan Hercberg , Maria del Pilar
        INRA
        , Bobigny  Cedex .
         UMR 1125 Epidémiologie Nutritionnelle; Hercberg , Serge
        INRA
        , Bobigny  Cedex .
         UMR 1125 Epidémiologie Nutritionnelle; Borel , Patrick
        INRA
        , Marseille .
         UMR 1260 Nutrition, Obésité et Risque Thrombotique

Effect of type of TAG fatty acids on lutein and zeaxanthin bioavailability

2013

GlEIZE , Beatrice (INRA , Marseille (France). UMR 1260 Nutrition, Obésité et Risque Thrombotique ) | Tourniaire , Franck (INRA , Marseille (France). UMR 1260 Nutrition, Obésité et Risque Thrombotique ) | Depezay , Laurence (Bonduelle, Villeneuve d'Ascq(France).) | Bott , Romain (INRA , Avignon (France). UMR 0408 Sécurité et Qualité des Produits d'Origine Végétale) | Nowicki , Marion (INRA , Marseille (France). UMR 1260 Nutrition, Obésité et Risque Thrombotique ) | Albino , Lionel (Bonduelle, Villeneuve d'Ascq(France).) | Lairon , Denis (INRA , Marseille (France). UMR 1260 Nutrition, Obésité et Risque Thrombotique ) | Kesse-Guyot , Emmanuelle (INRA , Bobigny Cedex (France). UMR 1125 Epidémiologie Nutritionnelle) | Galan Hercberg , Maria del Pilar (INRA , Bobigny Cedex (France). UMR 1125 Epidémiologie Nutritionnelle) | Hercberg , Serge (INRA , Bobigny Cedex (France). UMR 1125 Epidémiologie Nutritionnelle) | Borel , Patrick (INRA , Marseille (France). UMR 1260 Nutrition, Obésité et Risque Thrombotique )

The xanthophylls lutein and zeaxanthin probably play a role in visual function and may participate in the prevention of age-related eye diseases. Although a minimum amount of TAG is required for an optimal bioavailability of these carotenoids, the effect of the type of TAG fatty acids (FA) is less clear. The aim was to assess the effect of the type of TAG FA on bioavailability of these xanthophylls. A total of three complementary models were used: an in vitro digestion model to study bioaccessibility, Caco-2 cells to study uptake efficiency and orally administered rats to study in vivo bioavailability. Results showed that lutein and zeaxanthin bioaccessibility was greater (about 20-30%, P < 0.05) with butter and palm oil than with olive and fish oils. Mixed micelle size, which was significantly lower (about 8%, P<0.05) with SFA than with unsaturated FA, was inversely related to lutein and zeaxanthin bioaccessibility. There was no significant effect of the type of TAG FA on xanthophyll uptake by Caco-2 cells, but some compounds present in natural oils significantly affected xanthophyll uptake. Oral administration of rats with spinach and butter over 3 d led to a higher fasting plasma lutein concentration than oral administration with olive or fish oils. In conclusion, dietary fats rich in SFA lead to a higher bioavailability of lutein and zeaxanthin, as compared with fats rich in MUFA and PUFA. This is due partly to the higher bioaccessibility of these xanthophylls in the smaller mixed micelles produced when SFA are incorporated into mixed micelles.

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