Effect of orally administrated L-arginine on MIA-induced osteoarthritis in rats
2009
A. Nor Jawahir | S. Ganabadi | A. K. Arifah | H. C. Chen
Effects of oral administration L-arginine were evaluated on experimentally-induced OA.Rats were induced with OA by intra-articular injection of 3mg/joint monosodium iodoacetate in their right stifle joint (day 0). After 17 days of inductions, 1.25 g/kg of L-arginine were given orally to the first group, 30 mg/kg of celecoxib for second group and normal saline for the control group. Upon euthanasia (day 45), samples of joint were collected. The joints were observed grossly and processed for hematoxylin and eosin, and safranin-O fast green staining. Changes on the cartilage surface of the induced joint and thickening of the joint capsule were more severe in group treated with normal saline. Histopathological changes such as disorganization of chondrocytes, erosion and fibrillation of cartilage surface, subchondral changes and osteophyte formation were more severe in control group compared to L-arginine treated group. This study suggests that oral administration of L-arginine has protective effects on cartilage and may be an alternative treatment for OA.
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