Clinical toxicological investigations on acute carbofuran intoxication in dogs

Английский. The present studies were conducted to evaluate the toxic effects of the carbamate in­sec­ticide carbofuran (Carbosan 35 СТ) after experimental acute intoxication in dogs. The experiments included one control and five experimental groups (total number of 42 dogs), treated with increasing single doses of the preparation via an oesophageal tube as followed: experimental group I: 0.525 mg/kg, experimental group II: 1.05 mg/kg

experimental group III: 2.1 mg/kg

experimental group IV: 3.5 mg/kg and experimental group V: 5.25 mg/kg, corresponding to 1/20 LD50, 1/10 LD50, 1/5 LD50, 1/3 LD50 and 1/2 LD50 - oral doses for albino rats, respectively. The clinical status of all grous was followed out three consecutive days prior to the treatment (hours –48, –24 and 0) and 1, 3, 5, 7, 24 and 48 hours thereafter to evaluate rectal body temperature, heart and respiratory rates, faeces and urine excretion, locomotion, and perception. It was found out that the first toxic effects were observed at a dose of 1.05 mg/kg (1/10 of LD50 for albino rats), the first lethal issues occurred at 5.025 mg/kg (1/2 of LD50 for albino rats) and the dose provoking 100% lethality was 10.5 mg/kg, which was equal to LD50 for albino rats. The toxicity of the tested carbamate insecticide was clinically expressed by hyperthermia, tachycardia and polypnea hypersalivation, staggering, wandering gaze, bruxism, vomiting, faecal and urine incontinence, tremor, convulsions, seizures, clonic spasms, paresis and paralysis of limbs.