Anti-inflammatory effects of Houttuynia cordata supercritical extract in carrageenan-air pouch inflammation model
2012
Kim, D.J., Chungbuk National University, Cheongju, Republic of Korea | Park, D.S., Chungbuk National University, Cheongju, Republic of Korea | Kyung, J.B., Chungbuk National University, Cheongju, Republic of Korea | Yang, Y.H., Chungbuk National University, Cheongju, Republic of Korea | Choi, E.K., Chungbuk National University, Cheongju, Republic of Korea | Lee, Y.B., Central Research Institute, Dr. Chung's Food Co., Ltd., Cheongju, Republic of Korea | Kim, H.K., Institute of Life Science Research, Rexgene Biotech, Cheongweon, Republic of Korea | Hwang, B.Y., Chungbuk National University, Cheongju, Republic of Korea | Kim, Y.B., Chungbuk National University, Cheongju, Republic of Korea
Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in rat carrageenan-air pouch model. Oral administration of HSE (50-200 mg/kg) suppressed carrageenaninduced exudation and albumin leakage, as well as inflammatory cell infiltration at a high dose (200 mg/kg). Intraperitoneal injection of dexamethasone (2 mg/kg) only decreased exudation and cell infiltration, while indomethacin (2 mg/kg, i.p.) reduced exudate volume and albumin content without influence on the cell number. HSE lowered tumor-necrosis factor-α (TNF-α) and nitric oxide (NO), as well as prostaglandin E₂ (PGE₂). Dexamethasone only reduced TNF-α and NO, while indomethacin decreased PGE₂. The results indicate that HSE exhibits anti-inflammatory effects by inhibiting both TNF-α-NO and cyclooxygenase-2-PGE₂ pathways.
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