Four-Week Repeated Oral Toxicity Study of Leuconostoc citreum GR1 in Rats
2013
Kim, A.R., Chosun University, Gwangju, Republic of Korea | Lee, M.Y., Chosun University, Gwangju, Republic of Korea | Chang, H.C., Chosun University, Gwangju, Republic of Korea | Lee, J.J., Chosun University, Gwangju, Republic of Korea
This study was performed to investigate the repeated-dose toxicity of Leuconostoc citreum GR1 (Leuc. citreum GR1), a lactic acid bacterium isolated from kimchi, in male and female rats. Sprague-Dawley male and female rats were divided into four group (ten animals in each group) and Leuc. citreum GR1 was administered daily by gavage to rats at dosage levels of 0, 500, 1,000, or 2,000 mg/kg/day for four weeks. There were no bacterial- related deaths or abnormal clinical signs in either gender of rats during the observation period. Furthermore, no differences were found between the control and treatment groups in terms of body weight, food intake, and water consumption. Hematological parameters, serum biochemical analysis, and histopathological examination also showed insignificant dose-dependent alterations. There were also no alterations in organ weights upon administration of Leuc. citreum GR1 alone. These results suggest the oral application of Leuc. citreum GR1, up to a dosage level of 2,000 mg/kg, causes no adverse effects in both male and female rats.
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