Comparative phylogenetic analysis of Dobrava-Belgrade virus L and S genetic segments isolated from an animal reservoir in Serbia
Nikolić, Valentina (Faculty of Medicine, Belgrade (Serbia)) | Stajković, N. (Military Medical Academy, Belgrade (Serbia)) | Stamenković, Gorana (Institute for Biological Research Siniša Stanković, Belgrade (Serbia)) | Cekanac, R. (Military Medical Academy, Belgrade (Serbia)) | Marušić, P. (Institute of Public Health, Zaječar (Serbia)) | Jovanović, N. (Ministry of Defense, Belgrade (Serbia)) | Krstić, Milena (Military Medical Academy, Belgrade (Serbia)) | Mladenović, J. (Military Medical Academy, Belgrade (Serbia)) | Šiljić, Marina (Faculty of Medicine, Belgrade (Serbia)) | Gligić, Ana (Institute of Virology, Vaccines and Sera Torlak, Belgrade (Serbia)) | Stanojević, Maja (Faculty of Medicine, Belgrade (Serbia))
The Dobrava-Belgrade virus (DOBV) is a member of the Bunyaviridae family, genus Hantavirus, possessing a single-stranded RNA genome consisting of three segments, designated L (large), M (medium) and S (small). In this study, we present phylogenetic analysis of a newly detected DOBV strain isolated from Apodemus agrarius. Analysis was based on partial L and S segment sequences, in comparison to previously published DOBV sequences from Serbia and elsewhere. A phylogenetic tree based on partial S segment revealed local geographical clustering of DOBV sequences from Serbia, unrelated to host (rodent or human). The topology of the phylogenetic tree was confirmed with a high percent of com- pletely or partially resolved quartets in likelihood-mapping analysis, whereas no evidence of possible recombination in the examined S segment data set was found.
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