From southern Tunisia on gastrointestinal nematodes of sheep
2014
Akkari, H | Elandalousi, R Boubaker | Gharbi, M
Thymus capitatus (Lamiaceae) is used traditionally by people as spices and was reported to pos- sess some biological effects. The objective of this study was to evaluate the anthelmintic efficacy of T. capi- tatus in comparison to albendazole against the gastrointestinal (GI) nematodes of sheep. To fulfil the objectives, In vitro anthelmintic activities of crude aqueous (CAE) and ethanolic extracts (CEE) of aerial parts of T. capitatus were investigated on the egg and adult nematode parasite Haemonchus contortus. Both extract ty - pes of T. capitatus inhibited hatching of eggs completely at a concentration close to 2mgperml. LC50 of ethanolic extract of T. capitatus was 0.368 mg per ml while that of aqueous extract was 6.344 mg per ml. There was statis- tically significant difference between aqueous and ethanolic extracts (p less than 0.05). The ethanolic extract showed better in vitro activity against adult parasites than the aqueous one in terms of the paralysis and-or death of the worms at different hours post-treatment (PT). Dose dependent activity was also observed for both extract. As far as the literature could be ascertained, there is no published report on anthelmintic activity of T. capitatus. The results of the present study suggest that T. capitatus extracts are a promising alternative to the commercially available anthelmintics for the treatment of GI nematodes of small ruminants.
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