Antihypertensive effect of ethanol extracts of Aralia elata in spontaneously hypertensive rats
2017
Jin, J.Y., Jeju National University, Jeju, Republic of Korea | Park, E.H., Jeju National University, Jeju, Republic of Korea | Jeon, Y.A., Jeju National University, Jeju, Republic of Korea | Lee, Y.J., Jeju National University, Jeju, Republic of Korea
Antihypertensive effects of ethanol extracts of Aralia elata (Miq.) Seem. (AE) were investigated in spontaneously hypertensive rats (SHR). SHR aged 14 weeks were treated for 8 weeks with AE (10 or 50 mg/kg/day) or amlodipine besylate (Am; 10 mg/kg/day) orally. Hypertension results in injury to several organs and can produce a significant increase in malondialdehyde (MDA) content as a result of lipid peroxidation and endothelial dysfunction. In this study, oral administration of AE and Am significantly reduced systolic blood pressure, organ weight index, and MDA content in tissues but increased significantly the plasma nitrite and nitrate concentrations. The endothelium-dependent relaxant activities of acetylcholine in norepinephrine (NE)-precontracted aorta were increased in AE- and Amtreated rats. Particularly strong endothelium-dependent relaxant activities were observed in AE-treated (50 mg/kg) rats. The endothelium-independent relaxant activities of sodium nitroprusside in NE-precontracted aorta were not changed. The results of this study suggest that AE has both antihypertensive and end-organ protective effects in SHR.
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