In vitro antiviral, anti-inflammatory, and antioxidant activities of the ethanol extract of Mentha piperita L.
YuXian Li, Jilin Agricultural Science and Technology College, Jilin, China | YiBo Liu, Longhua Hospital of Shanghai University of TCM, Shanghai, China | AiQin Ma, Shanghai Fengxian District Central Hospital, Shanghai, China | Yong Bao, University of Minnesota, Minneapolis, USA | Man Wang, Shanghai Fengxian District Central Hospital, Shanghai, China | ZhenLiang Sun, Shanghai Fengxian District Central Hospital, Shanghai, China
The objective of this study is to investigate the antiviral, anti-inflammatory, and antioxidant effects of the ethanol extract of Mentha piperita L. leaves (MPE). M. piperita L. leaves were extracted by reflux with ethanol. Total phenolic acid and total flavonoid content were determined. The antiviral activity of MPE against the respiratory syncytial virus (RSV) and the anti-inflammatory activity were evaluated in vitro. The levels of key preinflammatory mediators and cytokines including nitric oxide (NO), tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-6, and prostaglandin E2 (PGE2) were determined. The antioxidant activities were also evaluated using a colorimetry method. MPE contained high levels of phenolic acid and flavonoid, showed antiviral activity against RSV with a high selectivity index, and significantly decreased the production of NO, TNF-alpha, IL-6, and PGE2 in lipopolysaccharide-stimulated RAW 264.7 cells. Meanwhile, MPE showed potential free-radical scavenging activities. These results indicate that Mentha piperita L. might be a good source of medicinal plants.
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