rezistencija na antibiotike kod bakterija mlečne kiseline - rod Lactococcus / Resistance to antibiotics in Lacid acid bacteria - strain Lactococcus
2015
Filipić, Brankica (Farmaceutski fakultet, Beograd (Srbija). Katedra za mikrobiologiju i imunologiju) | Golić, Nataša (Institut za molekularnu genetiku i genetičko inženjerstvo, Beograd (Srbija)) | Jovčić, Branko (Biološki fakultet, Beograd (Srbija)) | Ćupić-Miladinović, Dejana (Fakultet veterinarske medicine, Beograd (Srbija)) | Soković, Svetlana (Institut za molekularnu genetiku i genetičko inženjerstvo, Beograd (Srbija)) | Popović, Dušanka (Institut za molekularnu genetiku i genetičko inženjerstvo, Beograd (Srbija)) | Kojić, Milan (Institut za molekularnu genetiku i genetičko inženjerstvo, Beograd (Srbija))
Lactic acid bacteria (LAB) are widely used in the food industry, especially in the pro- duction of fermented dairy products and meat. The most studied species among LAB is Lactococcus lactis. L. lactis strains are of great importance in the production of fermented dairy products such as yogurt, butter, fresh cheese and some kind of semi-hard cheese. Although L. lactis acquired the „Generally Regarded As Safe“ (GRAS) status, many investigations indicated that lactococci may act as reservoirs of antibiotic resistance genes, which could be transferred to other bacterial species in human gastrointestinal tract includ- ing pathogens. The genome analysis of L. lactis indicated the presence of at least 40 putative drug transporter genes, and only four multidrug resistance (MDR) transporters are functional- ly characterized: LmrA, LmrP, LmrCD i CmbT. LmrA is the first described MDR transport- er in prokaryotes. LmrCD is responsible for resistance to cholate, which is an integral part of human bile and LmrCD is important for intestinal survival of lactococci that are used as probiotics. Secondary multidrug transporter LmrP confers resistance to lincosamides, mac- rolides, streptogramins and tetracyclines. CmbT protein has an effect on the host cell re- sistance to lincomycin, sulfadiazine, streptomycin, rifampicin, puromycin and sulfametox- azole. Since the food chain is an important way of transmitting resistance genes in human and animal population, it is of great importance to study the mechanisms of resistance in lactococci and other LAB, intended for the food industry. Key
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