A Conformational Isomer of Soulattrolide from the Stem Bark of Calophyllum symingtonianum and Its Antibacterial Activity
2018
Deny Susanti, International Islamic University Malaysia, Kuantan, Malaysia | Nissad Attoumani, International Islamic University Malaysia, Kuantan, Malaysia | Muhammad Taher, International Islamic University Malaysia, Kuantan, Malaysia | Mohd Fazlin Rezali, SIRIM Berhad (National Metrology Laboratory), Lot PT 4803, Bandar Baru Salak Tinggi, 43900 Sepang, Selangor, Malaysia | Md. Hossain Sohrab, Pharmaceutical Sciences Research Division, BCSIR Laboratories Dhaka, Dr. Qudrat-I-Khuda Road, Dhanmondi, Dhaka-1205, Bangladesh | Choudhury Mahmood Hasan, Manarat International University, Dhaka, Bangladesh | Zainul Amiruddin Zakaria, Universiti Putra Malaysia, Selangor, Malaysia
Callophylum symingtonianum (Guttiferae), an evergreen broad-leaved tree that usually grows in hill forests, can be found distributed in the Malay Peninsula. The barks, leaves, flowers and seeds is often used medicinally to treat diarrhea and rheumatism. In the present study, we isolated two inophyllum type coumarins, 12-O-ethylinophyllum D (1) and iso-soulattrolide (2) from the stembarks of C. symingtonianum together with their antibacterial activity. The compounds were isolated by chromatographic methods on a silica gel. The structures were established by spectroscopic methods including UV, IR, (1D and 2D) NMR and mass spectrometry as well as by comparison with several literature sources. The antibacterial activity of those compounds was tested using a disc-diffusion assay against Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa. Both compound exhibited mild inhibition against P. aeruginosa with both 111 μg/ml MIC value. Compound 2 also inhibits S. aureus with 25 μg/ml MIC value.
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