Immune-enhancement effects of tuna cooking drip and its enzymatic hydrolysate in Balb/c mice
Kim, M.J., Pukyong National University, Busan, Republic of Korea | Kim, K.B.W.R., Pukyong National University, Busan, Republic of Korea | Sung, N.Y., Kongju University, Kongju, Republic of Korea | Byun, E.H., Kongju University, Kongju, Republic of Korea | Nam, H.S., Dongwon F and B, Seongnam, Republic of Korea | Ahn, D.H., Pukyong National University, Busan, Republic of Korea
Tuna cooking drip (TCD) is a protein rich byproduct of canned tuna processing that is typically discarded. In this study, the immune-enhancing activities of TCD and its enzymatic hydrolysate (EH-TCD) were investigated by intraperitoneally administering Balb/c male mice with TCD and EH-TCD for 2 weeks. This administration resulted in an increase in the weight of the spleen and thymus (200-800 mg/kg) and enhanced the proliferation rates of splenocytes (200-800 mg/kg). TCD and EHTCD significantly increased the production of immunostimulatory cytokines (interleukin-10 and interleukin-2). In addition, TCD and EH-TCD increased serum IgG1 and IgG2a levels in a concentration-dependent manner. Particularly, EH-TCD had a greater immune-enhancing effect than TCD. These results suggest that TCD and EH-TCD exert immune-enhancing effects through an IgG antibody response and T cell activation, and EH-TCD can be used as an immunostimulatory agent.
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