Preventative activity of kimchi on high cholesterol diet-induced hepatic damage through regulation of lipid metabolism in LDL receptor knockout mice
Woo, M., Pusan National University, Busan, Republic of Korea | Kim, M., Pusan National University, Busan, Republic of Korea | Noh, J.S., Tongmyong University, Busan, Republic of Korea | Park, C.H., National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong, Republic of Korea | Song, Y.O., Pusan National University, Busan, Republic of Korea
This study investigated the effect of kimchi on hepatic lipid metabolism and inflammatory response. Lowdensity lipoprotein receptor knockout mice fed high cholesterol diet (HCD) with an oral administration of kimchi methanol extracts (KME, 200 mg kg bw-¹ day-¹ ) or distilled water for 8 weeks (n = 10 per group). Compared with the control group, plasma and hepatic lipid concentrations were lower in the kimchi group (p less than 0.05), which was confirmed with hepatic histological examination by Oil Red O staining. Hepatic expressions for fatty acid synthesis were downregulated whereas those for beta-oxidation were upregulated in the kimchi group (p less than 0.05). Hepatic expressions for cholesterol synthesis were decreased but those for cholesterol export was increased in the kimchi group (p less than 0.05). Moreover, kimchi intake reduced expression for inflammatory cytokines (p less than 0.05). Kimchi exerted beneficial effects on HCD-induced hepatic damage by suppressing lipid synthesis and inflammation, and facilitating fatty acid oxidation and cholesterol excretion.
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