Repressive effects of red bean, Phaseolus angularis, extracts on obesity of mouse induced with high-fat diet via downregulation of adipocyte differentiation and modulating lipid metabolism
Park, Y.M., Andong National University, Andong, Republic of Korea | Kim, J.I., Andong National University, Andong, Republic of Korea | Seo, D.H., Biotechnology R and D Center, Cell Biotech, Gimpo, Republic of Korea | Seo, J.H., National Medical Center, Seoul, Republic of Korea | Lim, J.H., Andong National University, Andong, Republic of Korea | Lee, J.E., Andong National University, Andong, Republic of Korea | Choi, J.Y., Kyungpook National University, Daegu, Republic of Korea | Seo, E.W., Andong National University, Andong, Republic of Korea
Obesity is generally caused by quantitative changes in adipocyte differentiation and fat metabolism. Only a few studies have been determined the effect of red beans extract on obesity and plasma cholesterol concentration. We have been studied the functional activities of red-bean extracts including anti-oxidative effect against DNA and cell damages. Histological study including micro CT analysis showed that the accumulation of fat in hepatocytes and intestines was significantly decreased in red bean extract treated group. In addition, plasma cholesterol and triglyceride levels were decreased in blood samples. In addition, it was confirmed that the red bean extract inhibited the expression of PPARc, Fabp4 and RETN genes, which regulate total adipocyte differentiation and lipid metabolism. Red bean extract inhibits the expressions of transcription factors associated with adipocyte differentiation in a dose-dependent manner, thereby inhibiting fat accumulation and decreasing blood lipid levels in obese mice induced by high fat diet.
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