Glycyrrhetic acid monoglucuronide: sweetness concentration- response and molecular mechanism as a naturally high-potency sweetener
2019
Yang, Y.A., Elion-Nature Biological Technology Co., Ltd, Nanjing, China | Wei, Y.G., Elion-Nature Biological Technology Co., Ltd, Nanjing, China | Guo, X.N., Elion-Nature Biological Technology Co., Ltd, Nanjing, China | Qi, P.F., Nanjing University, Nanjing, China | Zhu, H.L., Nanjing University, Nanjing, China | Tang, W.J., Elion-Nature Biological Technology Co., Ltd, Nanjing, China
Glycyrrhetic acid monoglucuronide (GAM) is obtained from the natural sweetener glycyrrhizin through enzymolysis. Its sweetness concentration-response (C-R) behavior in room-temperature in water was determined using two-alternative forced choice discrimination tests. The C-R equation of resultant hyperbolic curve relating sucrose equivalent (SE, %) to GAM concentration ([GAM], mg/L) was SE = 19.6 X [GAM]/ (194.8 + [GAM]). From the C-R function, Pw (2) of GAM, relative to a 2% (w/v) sucrose reference, is more than 900, which has much higher potency than its precursor glycyrrhizin. Molecular modeling showed that GAM is finely bound into protein 1EWK through conventional hydrogen bonds, π-Alkyl interactions and Van der Waals bonds, which exhibited better protein inclusion than Glycyrrhizin. Thus, GAM could be developed as a new zerocalorie, naturally high-potency sweetener.
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