Effects of total replacement of fish-based diet with plant-based diet on the hepatic transcriptome of European sea (Dicentrarchus labrax)
2011
Geay, F., | Ferraresso, S., | Zambonino-Infante, Jose-Luis | Bargelloni, L., | Quentel, C., | Vandeputte, Marc, | Kaushik, Sadasivam, | Cahu, C.L., | Mazurais, David
The objective of the present study was to analyse the effects of the replacement of a fishbased diet (FD) by a plant-based diet (VD), on the hepatic transcriptome of a strict carnivorous fish species: the European sea bass (Dicentrarchus labrax). Oligo DNA microarrays investigation identified 582 unique annotated genes differentially expressed between dietary groups. Several genes involved in the LC-PUFA and cholesterol biosynthetic pathways were found to be up-regulated in fish fed VD, suggesting a stimulation of the lipogenic pathways. Biological processes related to protein catabolism, amino acid transaminations, carbohydrate catabolism and blood coagulation were also found to be regulated by diet. In addition, the combination of our transcriptomic data with an analysis of plasmatic immune parameters revealed a stimulation of complement activity associated with an immunodeficiency in the fish fed VD.
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