Regulatory process towards the delivery of beta-carotene-enhanced golden rice to help improve nutritional status in the Philippines
2019
Swamy, B.P.M. | Ordonio, R.L. | Marundan, S., Jr | Samia, M. | Rebong, D.B. | Miranda, R.T. | Apongol, Ma.A.T. | Alibuyog, A.Y. | Suralta, R.R. | Reinke, R.F. | Bancodin, R. | Mackenzie, D.J.
Golden Rice (GR) is a new type of rice produced through modern biotechnology that is biofortified with beta carotene (vitamin A precursor), GR is intended to complement other vitamin A sources in the diet, and is viewed as a potential intervention to address vitamin A deficiency in rice-consuming countries. It is estimated that such deficiency affects about 2.1 million children in the Philippines. From 2015 wet season to 2016 dry season, PhilRice [Philippine Rice Research Inst., Nueva Ecija, Philippines] and IRRI [International Rice Research Inst., Metro Manila, Philippines] have conducted two seasons of confined field testing (CFT) of Golden Rice event E (GR2E) lines in the garlic background of PSB Rc 82. Here authors present the selection of the best-performing PSB Rc 82 GR2E introgression lines and the result of the compositional analysis in GR2E, both in the context of biosafety regulatory compliance. Based on yield and agro-morphological performance, authors selected five promising PSB Rc 82 GR2E lines. These lines showed comparable yield, agro-morphological characteristics, and pest and disease response to the original recipient variety (PSB Rc 82). As of the compositional analysis of bulked Golden Rice grains, it was found that PSB Rc 82 GR2E was similar in terms of chemical composition with ordinary rice, except for the intended bioavailability of beta-carotene. This provides clear initial evidence as to the safety of GR2E based on the principle of substantial equivalence. All the five promising introgression lines, along with the control, will be further tested under field trial conditions in two sites in the Philippines in 2019, will bring us closer to releasing safe and nutritious Golden Rice to improve the nutritional status of Filipino populations at risk of vitamin A deficiency.
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