THE EFFECT OF EIMERIOTIC INVASION ON THE ORGANISM OF RABBITS

Coccidiosis remains one of the most serious problems of the digestive organs of productive animals, including rabbits. Theaim of this research was to determine the degree of pathogenic effect of eimeria at a specific intensity of invasion on the bodyof purebred and hybrid rabbits.The scientific experiment was carried out on Chinchilla rabbits and their hybrids with the California breed at the age of 1.5months. In total, groups of pairs of analogs of 6 heads were formed. Newborn rabbits of the experimental groups wereexperimentally infected with Eimeria at a dose of about 100 thousand oocysts per head.On the 45th day of infection, blood samples were taken for biochemical and clinical analysis, animals of experimental andcontrol groups were slaughtered, and the material for histological examination was selected from the small and large intestines,lymph nodes, liver, and spleen.The results of the research showed that with the intensity of invasion of 100 thousand oocysts per animal, clinical andbiochemical blood samples do not reflect the pathological processes occurring in the wall of the small intestine. The authorsalso did not observe eosinophilia in the blood characteristic of parasite damage; however, there was a slight increase in thepercentage of segmented neutrophils compared to the control group animals: in purebred chinchillas from 35.83 ? 0.87 to 36 ?0.63, and in hybrids ? from 42.83 ? 1.08 to 44.67 ? 1.33, which indicated the presence of inflammatory processes andmoderate intoxication in the body of infected animals.A decrease in the albumin content by 29.1-50.19%, depending on the breed, against the background of an increase in thelevel of globulins in blood plasma, in the opinion of the authors, is due to both inflammatory reactions in the wall of the smallintestine, which is accompanied by a violation of the processes of digestion and absorption as well as possible against thebackground of tissue damage by the influence of toxic products of the breakdown of mucosal cells on the liver. In the smallintestine, damage to enterocytes as well as accumulations of lymphocytes and eosinophils were found in histological sectionsat the sites of localization of meronts and merozoites.