In vitro inhibition of adhesion of Escherichia coli strains by Xylitol
Silva, Annelisa Farah da(Universidade Federal de Juiz de Fora Faculdade de Farmácia) | Suzuki, Érika Yoko(Universidade Federal de Juiz de Fora Faculdade de Farmácia) | Ferreira, Aline Siqueira(Universidade Federal de Juiz de Fora Faculdade de Farmácia) | Oliveira, Murilo Gomes(Universidade Federal de Juiz de Fora Faculdade de Farmácia) | Silva, Sílvio Silvério da(Universidade de São Paulo Escola de Engenharia de Lorena Departamento de Biotecnologia,Faculdades Integradas Teresa D'Ávila) | Raposo, Nádia Rezende Barbosa(Universidade Federal de Juiz de Fora Faculdade de Farmácia ,Universidade de São Paulo Faculdade de Medicina Laboratório de Neurociências)
The present study aimed to evaluate xylitol's antimicrobial and anti-adherence activities on Escherichia coli (ATCC 8739) and on another clinical strain enteropathogenic E. coli (EPEC). In vitro minimum inhibitory concentration (MIC) test and adhesion assays were performed using 0.5, 2.5 and 5.0% xylitol. It was found that xylitol did not have antimicrobial properties on these strains. The scanning electron microscopy (SEM) demonstrated that the slides treated with xylitol had a significant reduction in the number of bacilli and the inhibition of microbial adhesion was probably the xylitol's mechanism of action. Xylitol could be a possible alternative on the control of E. coli infections.
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