A study on the hepatoprotective effect of Andrographis paniculata on mice
2010
Sutha D. | Jegathambigai R. | Sudhakaran S.
Andrographis paniculata is a well known medicinal plant of Ayurveda with various pharmacological as well as medicinal properties. The present study determined the hepatoprotective effect of crude methanolic extracts of A. paniculata on mice. The phytochemical screening of the crude methanolic extracts of A. paniculata plant was also determined followed by the confirmation of the active compound using Thin Layer Chromatography. The hepatoprotective activity of methanolic extracts of A. panicufata was evaluated against paracetamol induced (500mg/kg) hepatic damage in mice. The extracts at doses of 10mg/kg and 1OOmg/kg were orally administered at 24 and 72 hours time interval n each group. Histological analysis of the liver and the liver protein content was determined. The results of the study indicated that the crude extracts of A. paniculata at both doses exhibited a significant protective effect in the liver morphology of the paracetamol induced hepatotoxicity in mice. There was also a significant decrease (P<0.05) the liver protein content of the hepatotoxic mice after the treatments. The crude methanolic extracts of A. paniculata indicated the presence of phytochemical constituents such as flavonoid, alkaloid, tannin and terpenoids. Finally, Thin Layer Chromatography confirmed the presence of active compound, diterpene lactone or andrographolide which has contributed to the hepatoprotective activity of A paniculata Hence, it can be concluded that treatment of low and high doses of A paniculata with time period revealed the hepatoprotective effect in mice.
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