Cisteīnu un selēncistīnu saturošo peptīdu modificēšana elektrofīlās ciklizācijas un redzamās gaismas iniciētās reakcijās: promocijas darba kopsavilkums
2022
LapcinskaLapčinska, Sindija, Sindija
The Doctoral Thesis has been prepared as a collection of thematically related scientificpublications that includes six scientific publications. Simple and efficient methods for functionalization of cysteine and selenocystine-containing peptides were established based on the generation of sulfenyl or selenyl electrophile. The electrophilic species were subsequently used in 5- and 6-endo-dig cyclization reactions yielding (hetero)cyclic systems. Novel atom-economic methods were developed for modification of selenocystine-containing peptides under visible light irradiation.
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