What is the best animal model for Leishmaniasis studies?
2018
Akkucuk, Serife | Kaya, Ozlem Aycan | Yaman, Mehmet
Leishmaniasis is a zoonotic disease which has worldwide importance and is hard to control and treat. Researchers have not yet developed a protective vaccine for humans in the light of current studies. Various experimental animal models are being used since; i) Leishmania has different species and vectors, ii) there are still many clinical, pathological and immunological issues that have to be investigated, iii) new non-toxic medical recipes to have maximum yield in a short time have to be investigated, iv) protective vaccination have to be developed. Mouse, hamster, dog, rodent, and non-human primates are among these animal models. None of them has the same clinical features, pathogenesis and immunology with the disease in human. However, rodents, dogs, and monkeys, which are the last host of the parasite, are among the most preferred models in recent days. Considering the different clinical forms of the disease, it is best to decide which Leishmania species to work with which animal. This review is intended to guide the researchers in choosing an appropriate animal model for leishmaniasis studies.
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