Synthesis of small intestine mucosa glucoso-6-phosphatase in the course of experimental coccidiosis of suckling piglets
1991
Kudweis, M. (Vyzkumna a Diagnosticka Histochemicka Laborator Nemocnice, Cesky Krumlov (CSFR)) | Lojda, Z. | Julis, I. | Lenhardt, L. | Marcanik, J.
Glucoso-6-phosphatase activity (EC. 3.1.3.9.) was evaluated microdensitometrically in the small intestine mucosa of 19 conventional piglets infected with Eimeria debliecki oocysts (infection dose of 200 000 oocysts) on day 1 after delivery (DAD). The synthesis of the observed hydrolase was followed within days 1 to 10 after infection (DAI). The activity of the same enzyme was also determined in four control conventional piglets at the age of two to five days. The small intestine mucosa of healthy piglets was found to have relatively balanced glucoso-6-phosphatase concentrations in all observed sections (duodenum, middle and posterior jejunum and ileum). The topographic gradient failed to be demonstrated in control piglets. In piglets experimentally infected with E. debliecki the glucoso-6-phosphatase activity was decreasing during infection already since DAI 1. The enzyme hypoactivity was still lower in the following days and reached the minimum value at the end of the target period (DAI 10), when its value made only 33 per cent of the concentration recorded in the intestine mucosa of control piglets. The topographic predisposition to the lower activity of glucoso-6-phospahtase was not found to be high. The only exception are DAI 6 and 7, when the lowest enzyme concentration was observed in the duodenum mucosa (52 per cent on DAI 6; 54 per cent on DAI 7). The activity of the observed enzyme was higher in the other sections of small intestine (57 per cent on DAI 6; 62 per cent on DAI 7).
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