Immunotoxicology and veterinary medicine (Review)
1999
Kacmar, P. | Pistl, J. | Mikula, I. (Univerzita Veterinarskeho Lekarstva, Kosice (Slovak Republic))
The present study emphasizes that the assessment of immunotoxicological risk arising from xenogenous substances demands the development of new and more exact immunotoxical testing methods. Moreover, the thorough evaluation of the immunotoxic effect of a respective xenobiotic should be supported by a complex set of tests rather than limited number of them. The extent of functional and non-functional immunity tests shoud be determined on the basis of knowledge about the mechanism of the toxic effects of xenobiotics in animals. This knowledge can be supplied by biochemistry, toxicology, pharmacology and histopathology (histochemistry and immunohistochemistry). The up-to-date knowledge about immunosuppressive effects of pesticides and their possible interference with the genetic material of live organisms indicates that it is necessary to restrict gradually the extensive use of a broad spectrum of pesticides through accentuated application of scientifically justified agrotechnical procedures and the use of transgenic plants developed by molecular genetic methods.
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