Expression of heat shock proteins HSP70 in pigs with chronic affliction of lungs and their detection by an immunocytochemical method
2000
Koubkova, M. | Antalikova, L. | Rozinek, J. | Knotkova, V. | Jilek, F. (Ceska Zemedelska Univ., Prague-Suchdol (Czech Republic). Katedra Veterinarnich Disciplin)
The presence of heat shock proteins (HSP70) in pig pulmonary tissue was detected using an immunocytochemical method. The pigs underwent a respiratory disease leading to coalescenses of visceral and parietal pleurae and fibrous reparation in lungs in the past. During the pre-slaughter handling, acute processes as congestion, edema, and cracking of alveolar sides occurred in animals with chronic affections of lungs. These pathological changes were accompanied by stress response in single alveolar cells, especially granulated pneumocytes (type II cells). An increased expression of HSP70 was found in pulmonary macrophages as well, their number in alveolar lumen markedly increased. HSP70 positive response in vessels was abnormally increased in fibrous coalescenses, while other fibrous tissue was quite negative.
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