Prevention of fescue toxicosis
1989
Lipham, L.B. | Stuedemann, J.A. | Thompson, F.N. Jr
Abstract: A method, and compositions, for use in the prevention and treatment of fescue toxicosis in animals, especially cattle, sheep and horses, comprising administering to the animals a dopamine antagonist which does not cause adverse psychological or neurological effects. Useful dopamine antagonists are those specific for D2 receptors including metoclopramide, sulpiride, tiapride, alizapride and other substituted benzamides. The preferred compound is metoclopramide, a substituted benzamide having the formula 4-amino-5 chloro-N-[2-diethylamino)ethyl]-2-methoxy benzamide monohydrochloride monohydrate. The correct dosage can be determined from the combination of the behavioral response of the animal to the compound and by measuring the serum prolactin levels over time. In the preferred method, the compound is administered to the animals orally, using capsules, timed or slow release boluses, or as an additive in a salt, mineral, protein or energy block or animal feed, or as an implant.
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