Metabolic effects of histidine deficiency
1978
Clemens, Roger Allyn
An experiment, using histidine-deficient rats, was devised to test for other endogenous forms of histidine and whether the altered activities of histidine-degrading enzymes spares histidine. Research indicates that histidine is an essential amino acid in human beings. A review of the literature focused on the history of histidine research, the glucogenic pathway of histidine catabolism and histidine transamination of the four experiments conducted, 3 involved diets with varying histidine content and one diet was tyrosine and phenylalanine-free. Results indicate that histidine-deficient rats use carnosine and hemoglobin as endogenous sources of histidine; these substances could improve higher levels than necessary for maintenance for a short time. The histidine-sparing effect of HPT and HAL because of lowered activities during the first 13 days of a histidine-free diet may encourage incorporation of the limited supply of histidine into hepatic proteins.
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