Relationship between Ambient Fine Particles and Ventricular Repolarization Changes and Heart Rate Variability of Elderly People with Heart Disease in Beijing, China
2013
XU, Mei Mei | JIA, Yu Ping | LI, Guo Xing | LIU, Li Qun | MO, Yun Zheng | JIN, Xiao Bin | PAN, Xiao Chuan
OBJECTIVE: To explore the effects of particulate matters less than 2.5 μm in aerodynamic diameter (PM₂.₅) on heart repolarization/depolarization and heart rate variability (HRV). METHODS: We conducted a panel study for elderly subjects with heart disease in Beijing from 2007 to 2008. PM₂.₅ was measured at a fixed station for 20 h continuously each day while electrocardiogram (ECG) indexes of 42 subjects were also recorded repeatedly. Meteorological data was obtained from the China Meteorological Data Sharing Service System. A mixed linear regression model was used to estimate the associations between PM₂.₅ and the ECG indexes. The model was adjusted for age, body mass index, sex, day of the week and meteorology. RESULTS: Significant adverse effects of PM₂.₅ on ECG indexes reflecting HRV were observed statistically and the strongest effect of PM₂.₅ on HRV was on lag 1 day in our study. However, there were no associations between PM₂.₅ and ECG indexes reflecting heart repolarization/depolarization. Additionally, the effects of PM₂.₅ on subjects with hypertension were larger than on the subjects without hypertension. CONCLUSION: This study showed ambient PM₂.₅ could affect cardiac autonomic function of the elderly people with heart disease, and subjects with hypertension appeared to be more susceptive to the autonomic dysfunction induced by PM₂.₅.
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