Two 6-substituted 5,6-dihydro-alpha-pyrones from Ravensara anisata
1999
Andrianaivoravelona, J.O. | Sahpaz, S. | Terreaux, C. | Hostettmann, K. | Stoeckli-Evans, H. | Rasolondramanitra, J.
The leaves and bark dichloromethane extracts of Ravensara anisata showed antifungal activity against the yeast Candida albicans and the phytopathogenic fungus Cladosporium cucumerinum in bioautographic TLC assays. Activity-guided fractionation afforded two new alpha-pyrones: 6R*-(4R*-acetoxy-2S*-hydroxy-8-phenyloctyl)-5, 6-dihydro-2-H-pyran-2-one and 6R*-(2S*-acetoxy-4R*-hydroxy-8-phenyloctyl)-5, 6-dihydro-2-one. Their structures have been established by NMR spectroscopy, chemical methods and X-ray crystallographic analysis. The antifungal activity against C. albicans and C. cucumerinum was determined for both compounds.
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