Short term study of sucrose polyester a nonabsorbable fat like material as a dietary agent for lowering plasma cholesterol
1976
Fallat, R.W. | Glueck, C.J. | Lutmer, R. | Mattson, F.H.
Extract: The efficacy, safety, and acceptability of sucrose polyester (SPE), a fat like material that is neither digested nor absorbed, were assessed in 13 normal and 7 hypercholesterolemic subjects for its potential as a cholesterol lowering agent. Addition or substitution of SPE for culinary fats in thediets of the normocholesterolemic individuals produced a mean reduction of total and low density lipoprotein cholesterol of 14 and 17%, respectively. Total and low density lipoprotein cholesterol were not significantly reduced by similar 10 day feeding periods of SPE in seven subjects with familial hypercholesterolemia. On the basis of this short term evaluation in humans and other investigations with the rat and dog, SPE appears to have potential as a cholesterol lowering agent.
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