A ratiometric, fluorescent BODIPY-based probe for transition and heavy metal ions
2016
Qin, Wenwu | Dou, Wei | Leen, Volker | Dehaen, W. (Wim) | Van der Auweraer, Mark | Boens, Noël
A novel metal ion-sensitive fluorescent probe – 4,4-difluoro-8-(4-methylphenyl)-5-(phenylethynyl)-3-[bis(pyridin-2-ylmethyl)amino]-4-bora-3a,4a-diaza-s-indacene – based on the BODIPY platform with di(2-picolyl)amine as chelator has been synthesized and spectroscopically and photophysically characterized. The generalized treatment of the solvent effect shows that solvent dipolarity is primarily responsible for the observed shifts of the absorption and fluorescence emission maxima. Complex formation with various metal ions is investigated in acetonitrile solution by means of spectrophotometric and fluorometric titrations. The BODIPY indicator forms 1 : 1 complexes with several transition metal (Ni²⁺, Cu²⁺, Zn²⁺) and heavy metal (Cd²⁺, Hg²⁺) ions, producing large bathochromic shifts in the absorption and fluorescence spectra and, except for Ni²⁺, cation-induced fluorescence amplifications. The dissociation constants of the metal ion complexes range from 4 μM for Hg²⁺ to 48 μM for Zn²⁺.
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