Styrenes from the Seeds of Atalantia monophylla
2019
Sribuhom, Thurdpong | Thummanant, Yutthapong | Phusrisom, Suphanthip | Kukongviriyapan, Veerapol | Tontapha, Sarawut | Amornkitbamrung, Vittaya | Yenjai, Chavi
Four new dimeric styrenes, 1–4, were isolated from an EtOAc crude extract of the seeds of Atalantia monophylla. The biosynthetic pathway of 1 is proposed to involve a [2 + 2] cycloaddition, while 2–4 may be generated via a polar mechanism with a carbocation as the key intermediate. The structures of 1–4 were defined from spectroscopic analysis; experimental and calculated ECD spectra were used to characterize their absolute configurations. When tested against two different cancer cell lines, 1–4 were not determined to be cytotoxic (IC₅₀ > 10 μM).
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