Phytotoxicity and cytotoxicity of disesquiterpene and sesquiterpene coumarins from Ferula pseudalliacea
2014
Dastan, Dara | Salehi, Peyman | Ghanati, Faezeh | Gohari, Ahmad Reza | Maroofi, Hossein | Alnajar, Naba
Relative toxicity of a new disesquiterpene- and five sesquiterpene coumarins from the roots of Ferula pseudalliacea was investigated on tobacco cells, as a plant model cell line. The effects of these compounds on the germination of certain weeds and crop plants (from solanaceae) were evaluated as well. The cytotoxic effects of these compounds were also evaluated on human cancer cell line, HeLa. The highest inhibitory effect on the growth of tobacco cells was observed by sanandajin and farnesiferol B. Sanandajin also remarkably inhibited seed germination of all tested weeds and plants. Sanandajin, farnesiferol B, and kamolonol acetate displayed the highest potency against HeLa cells with IC50 of 2.2, 6.7, and 4.9μM, respectively. The results of the present investigation indicated that disesquiterpene and sesquiterpene coumarins isolated from F. pseudalliacea root extract can be considered as potent herbicides and cancer chemopreventive agents.
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