Paclitaxel structure-activity relationships and core skeletal rearrangements
1995
Chen, S.H. | Farina, V.
A number of novel paclitaxel (Taxol) analogs that contain modifications at the C2, C7 and C10 position have been prepared during the course of a taxol SAR study. These analogs include deoxygenated, fluorinated and C7-C19 cyclopropane paclitaxel derivatives. Several very interesting skeletal rearrangements within the taxol and baccatin core were also discovered while developing analog syntheses. The details of the chemistry and the biological evaluation of these analogs will be discussed.
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