Self-Assembly of Oligo- and Polypeptide-Based Amphiphiles: Recent Advances and Future Possibilities
2019
Machado, Craig A. | Smith, Ian R. | Savin, Daniel A.
Serving as a decades old answer to synthetic proteins, polypeptides possess beneficial chemical and mechanical characteristics as well as secondary structure that can lead to the formation of complex nanostructures. Utilizing these characteristics, scientists have strived toward developing “smart” materials to aid in drug delivery, wound healing, and tissue engineering. In this Perspective, we discuss some aspects of the current state of oligopeptide and polypeptide research and highlight important fields relating to the self-assembly of traditional polypeptides, peptide amphiphiles, hydrogels, protein–polypeptide conjugates, and multiarm or branched systems. This Perspective serves to highlight the recent (2015–present) advances in block oligo/polypeptides, specifically self-assembly of NCA-derived polypeptides, peptide amphiphiles, hydrogels, protein conjugation, and dendrimer/star polymers. Our primary focus is to outline the importance of oligo/polypeptide structure and nanoarchitecture and how these parameters dictate self-assembly and/or function.
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