Protection against homologous but not heterologous challenge induced by inactivated feline immunodeficiency virus vaccines
Hosie, M.J. | Osborne, R. | Yamamoto, J.K. | Neil, J.C. | Jarrett, O.
Whole inactivated virus vaccines from the FL4 cell line protected against challenge with homologous feline immunodeficiency virus (Petaluma strain) but not against a heterologous FIV isolate (GL-8) which is distinct from the Petaluma strain in virus neutralization. Protection was associated with a type-specific neutralizing antibody response and was retained when the challenge virus was propagated in an unrelated cell line.
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