Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. III. Identification of a mouse strain, P/N, that fails to respond to vaccination
1983
James, S.L. | Sher, A.
Schistosoma mansoni, 11 strains of inbred mice compared for their ability to develop resistance to challenge infection after vaccination with irradiated cercariae, two strains designated as high-responder strains to vaccination, 6 strains fell into intermediate category, one strain (P/N) consistently failed to respond to vaccination by development of significant levels of immunity to challenge infection, P/N mice have previously been characterized as deficient in their ability to mount delayed hypersensitivity reactions, produce lymphokine, and display macrophage activation for cytolysis of extra- and intracellular targets in other experimental systems
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