Soluble fibers prevent insulin resistance in hamsters fed high saturated fat diets
2006
Yokoyama, W.H. | Shao, Q.
Research is presented suggesting that intake of soluble fibre can overcome the adverse metabolic effects of diets high in saturated fats. The study used the Syrian hamster as an animal model. They were given a diet containing 5 or 20% fat (fat composition was 75% butterfat + 25% corn oil) alone or 20% fat plus a source of soluble fibre (barley or hydroxypropylmethylcellulose) for 4 wk and insulin resistance was measured using the euglycaemic insulinaemic clamp. Hepatic tissues were examined using TEM. Results show that dietary saturated fat caused insulin resistance, but that this was reversed by inclusion in the diet of soluble fibre. Enrichment of the high fat diet with soluble fibre also prevented the formation of fat vacuoles in hepatic tissue that occurred in the animals that received the high fat diet.
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