Bromopyridazinedione-mediated protein and peptide bioconjugation
2011
Chudasama, Vijay | Smith, Mark E. B. | Schumacher, Felix F. | Papaioannou, Danai | Waksman, Gabriel | Baker, James R. | Caddick, Stephen
Bromopyridazinedione-mediated bioconjugation to a cysteine containing protein and a disulfide containing peptide is described. The conjugates are cleavable in an excess of thiol, including cytoplasmically-relevant concentrations of glutathione, and show a high level of hydrolytic stability. The constructs have the potential for four points of chemical attachment.
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