Site of Action of Growth Inhibitory Tryptophan Analogues in Catharanthus roseus Cell Suspension Cultures
2014
Sasse, Florenz | Buchholz, Marita | Berlin, Jochen
Fourteen tryptophan analogues have been characterized with regard to their growth inhibitory effects on Catharanthus roseus cell cultures, their inhibitory effect on anthranilate synthetase, their incorporation into protein and their substrate affinity to tryptophan decarboxylase. The toxicity of 12 of the analogues was directly correlated with their inhibitory effect on anthranilate synthetase activity. None of the analogues was efficiently incorporated into protein. Only 4 of the analogues (4-methyl-, 4-fluoro-, 5-fluoro- and 5-hydroxytryptophan) were good substrates for tryptophan decarboxylase while all other analogues were rather poor substrates or were not converted at all. Alpha-methyltryptophan was a competitive inhibitor of tryptophan decarboxylase
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