Thiamin status of the elderly: dietary intake and thiamin pyrophosphate response
1994
Nichols, H.K. | Basu, T.K.
Objective: The present study was undertaken to investigate the relationship between thiamin intake and its biochemical status in 60 free-living (30 male, 30 female) elderly subjects (greater than or equal to 65 years). Design: Dietary intake was estimated using a 3-nonconsecutive-day food record. Biochemical status was assessed by measuring the stimulating effect of thiamin pyrophosphate (TPP) on transketolase activity (TPP effect) in hemolyzed erythrocytes, which is a functional test indicative of metabolic availability of thiamin. Results: Average daily thiamin intake was above the recommended requirement (> O.4 mg/1000 Kcal) for each gender; however, almost half of the total study population had TPP effect > 14%, suggesting thiamin deficiency. There was no correlation between thiamin intake and TPP effect. Conclusion: These findings raise questions about the reliability of dietary intake in assessing metabolic availability of thiamin in the elderly.
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