Thwarting protein synthesis leads to malaria parasite paralysis
2022
Mayoka, Godfrey | Woodland, John G. | Chibale, Kelly
Inhibiting translation presents a tantalizing strategy to tackle the most virulent human malaria parasite. Xie et al. disclose a compound that binds selectively to Plasmodium falciparum tyrosine aminoacyl-tRNA synthetase, preventing the incorporation of tyrosine into nascent proteins and paving the way for a new generation of safe, effective antimalarials.
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