Effect of weight loss by a low-fat diet and a low-carbohydrate diet on peptide YY levels
2010
Essah, P.A. | Levy, J.R. | Sistrun, S.N. | Kelly, S.M. | Nestler, J.E.
Objective: To compare the effects of weight loss by an energy-restricted low-fat diet vs low-carbohydrate diet on serum peptide YY (PYY) levels. Design: 8-week prospective study of 30 obese adults (mean age: 42.8±2.0 years, mean body mass index 35.5±0.6 kg m−2). Results: After 8 weeks, subjects on the low-carbohydrate diet lost substantially more weight than those on the low-fat diet (5.8 vs 0.99 kg, P<0.001). Weight loss by either diet resulted in a 9% reduction in both mean fasting serum PYY levels (baseline: 103.5±8.8 pg ml−1, after weight loss: 94.1±6.5 pg ml−1, P<0.01) and postprandial area under the curve (AUC) PYY (baseline: (20.5±1.5) × 103 pg h−1 ml−1, after weight loss: mean AUC PYY (18.8±1.4) × 103 pg h−1 ml−1, P<0.001). There was a trend towards lower levels of PYY with greater degrees of weight loss. Conclusions: Reduced PYY levels after weight loss by an energy-restricted low-fat or low-carbohydrate diet likely represents a compensatory response to maintain energy homeostasis and contributes to difficulty in weight loss during energy-restricted diets.
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