Regioselective C3–H Trifluoromethylation of 2H-Indazole under Transition-Metal-Free Photoredox Catalysis
2019
Murugan, Arumugavel | Babu, Venkata Nagarjuna | Polu, Ashok | Sabarinathan, Nagaraj | Bakthadoss, Manickam | Sharada, Duddu S.
Trifluoromethyl-substituted heteroarenes are biologically active compounds and useful building blocks. In this sequence, we have developed a visible-light-promoted regioselective C3–H trifluoromethylation of 2H-indazole under metal-free conditions, which proceeds via a radical mechanism. The combination of photocatalysis and hypervalent iodine reagent provides a practical approach to a library of trifluoromethylated indazoles in 35–83% yields.
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